齐拉西酮与氯氮平对精神分裂症患者认知功能的影响

目的探讨齐拉西酮对精神分裂症患者的认知功能的影响。方法用入院顺序分层随机法,将齐拉西酮与氯氮平治疗首发精神分裂症各60例作对照研究,在治疗前和治疗后2、4、8、12周末,用阳性症状及阴性症状量表（PANSS）,副反应量表（TESS）评定疗效及副反应,用韦氏成人智力量表（WAIS-R）、韦氏记忆量表（WMS）和威斯康星卡片分类测验（WCST）评定治疗前后患者认知功能的改变,分析量表中各领域的计分。结果两组PANSS总分在治疗后与治疗前比较差异有统计学意义（P〈0.01）,但氯氮平组副反应多。两组言语量表、操作量表、全量表和记忆量表分比治疗前明显提高。结论齐拉西酮治疗精神分裂症疗效显著,安全性高,对认知功能的改善彻底。

Effects of ziprasidone and clozapine on cognition function in schizophrenics

Objective To investigate the influence on cognition function of ziprasidone in schizophrenics.Methods Being used the vendom control stady,60 schizophrenic patients were treated with sisperidone as the controlled group.The Positive and Negative Syndrome Scale（PANSS）,while the adverse events were determined by the treatment emergent symptoms scale（TESS）,respectively WAIS-R,WMS,WCST were evaluated before treatment and after 2、4、8、12 weeks treatment.by menas of analyzing the scores in every domains.Results Two cent with total PANSS before treat after with treat relatively showed the difference of with on significance（P0.01）.The side effects were more in clozapine group than those in ziprasidone group.The language scale,operation scale,totalscale,and memoryscale were improved significantly in two group compared with befere treatment.Conclusion Ziprasidone has significant effectacy,higher safety,to the cognition the improvement of the function is thoroughly relief.