| 太白楤木总皂苷对HBV DNA的影响 |
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| 引用本文： | 崔大江,杨渭临,李秀丽. 太白楤木总皂苷对HBV DNA的影响[J]. 中西医结合肝病杂志, 2011, 21(4): 216-218. DOI: 10.3969/j.issn.1005-0264.2011.04.010 |
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| 作者姓名： | 崔大江 杨渭临 李秀丽 |
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| 作者单位： | 西安交通大学医学院第二附属医院干部三病区,陕西西安,710004 |
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| 基金项目： | 陕西省科学技术研究发展计划项目 |
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| 摘 要： | 目的：观察太白楤木总皂苷在体外对乙型肝炎病毒脱氧核糖核酸（HBV DNA）的影响。方法：以HepG2.2.15细胞为靶细胞,分别用不同浓度的太白楤木总皂苷和拉米夫定培养液培养,采用荧光定量PCR测定细胞外HBV DNA含量,评价太白楤木总皂苷对体外HBV DNA的抑制作用。结果：太白楤木总皂苷对体外培养HepG 2.2.15细胞分泌的HBV DNA 50%抑制浓度（IC50）为0.128g/L,治疗指数（TI）为5.11g/L。结论：太白楤木总皂苷具有一定的体外抗HBV作用。
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| 关 键 词： | 太白楤木 皂苷类 HepG2.2.15细胞 肝炎病毒,乙型 乙型肝炎病毒脱氧核糖核酸 |
Inhibitory effects of total saponin extracted from the Aralia Chinesis L against HBV DNA |
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| CUI DA-JIANG,YANG WEI-LIN,LI XIU-LI. Inhibitory effects of total saponin extracted from the Aralia Chinesis L against HBV DNA[J]. Chinese Journal of Integrated Traditonal and Western Medicine on Liver Diseases, 2011, 21(4): 216-218. DOI: 10.3969/j.issn.1005-0264.2011.04.010 |
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| Authors: | CUI DA-JIANG YANG WEI-LIN LI XIU-LI |
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| Affiliation: | CUI DA-JIANG,YANG WEI-LIN,LI XIU-LI.Third Area of Cadre Ward,The Second Affiliated Hospital,School of Medicine,Xi'an Jiaotong University(Xi'an Shanxi,710004)China |
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| Abstract: | Objective:To evaluate the inhibitory effects of the total saponin extracted from the Aralia Chinesis L.against hepatitis B virus(HBV) in vitro.Methods:HepG 2.2.15 cells as target cell were exposed to different concentrations of total saponin in and lamivudine respectively.PCR was applied to quqntify extracellular HBV DNA.Results:The 50% inhibitory concentration(IC50) of total saponin extracellular HBV DNA was 0.128g/L respectively,and treatment index(TI) was 5.23g/L respectively.Conclusion:The total saponin... |
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| Keywords: | Aralia Chinesis L.Saponis HepG 2.2.15 cell hepatitis B virus HBV DNA |
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