浅析不同来源贝母类药材在中成药中的质量控制

目前,药材市场中贝母类药材有川贝母、浙贝母、平贝母等多种贝母,容易导致混用、错用。因此,作者针对2010年版药典中贝母类药材的来源、检测指标及测定方法、所含生物碱类成分及其含量等方面进行综述。结果表明：2010年版药典中所收载的贝母的来源各不相同,性味归经及功能主治各有侧重。所含成分虽均多为生物碱类成分,但川贝母和伊贝母中所含特征生物碱成分为西贝母碱,平贝母和浙贝母多以贝母素甲、贝母素乙为对照进行薄层检查及含量测定。且贝母类药材中所含生物碱的量也各不相同。结论：控制中成药中贝母类药材的质量时应依据不同来源贝母类药材各自的特征性成分、含量高低相应的制定薄层鉴别、含量测定等质量标准,使制剂的质量标准更加准确且具有针对性。

Quality Control of Fritillary in Chinese Patent Medicines from Different Habitats

At present, kinds of fritillaries have emerged in medicine material market, such as Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Thunbergii and Fritillaria ussuriensis Maxim, which will easily lead to improper mixing and misuse. Thus, this paper briefly reviewed the different habitats, detection quota, detection methods, alkaloid content and constituents of fritillary in pharmacopeia published in 2010. The results indicated that the fritillaries recorded in pharmacopeia published in 2010 had different habitats, and the features and main functions were also different. Although the main content of fritillary is alkaloid, the characteristic alkaloid of Bulbus Fritillariae Cirrhosae and Bulbus fritillariae Pallidiflorae was imperaline. However, the content and thin-layer chromatography analysis of Peimine and Peiminine were mainly determined in Fritillaria ussuriensis Maxim and Bulbus Fritillariae Thunbergii, meanwhile, alkaloid content of fritillary was also different. Conclusion： Quality standard of fritillary medicine material including thin-layer chromatography and content analysis should be drafted according to characteristic constituent and content.