多项干预措施对抗菌药物临床应用的效果探析

目的:对比分析我院采取药学、行政等多项干预措施对抗菌药物临床应用的影响及干预效果,以便为今后制订更有针对性的干预措施提供参考。方法:通过回顾性调查方法,对采取多项干预措施前后我院住院患者抗菌药物使用强度(AUD)、用药频度(DDDs)、金额等进行统计、分析。结果:干预后,我院抗菌药物AUD总体呈下降趋势,2009-2012年AUD分别为44.8、42.2、37.9、38.7 DDDs/100人/天;人均抗菌药物使用金额从2009年的980元下降到2012年的641元;平均住院时间从2009年的19.0 d下降到2012年的14.2 d;抗菌药物使用率由2009年的69.7%下降到2012年的50.0%。结论:干预取得了较好效果,但在具体品种的选择等方面仍存在一定的不合理性。今后应根据存在的不足制订出更有针对性的干预措施,以使抗菌药物的使用更加规范、合理。

Analysis of the Effects of Multiple Intervention Measures on Clinical Use of Antibacterials

OBJECTIVE： To comparatively analyze the interventional effect of multiple intervention measures as pharmaceutical and administrative intervention on clinical use of antibacterials in order to provide reference for making more targeted interventions. METHODS： By retrospective study, the utilization of antibacterials was analyzed statistically in respects of AUD, DDDs, con- sumption sum, etc. RESULTS ： After intervention, the AUD of our hospital was in decreasing tendency on the whole. AUD were 44.8,42.2,37.9 and 38.7 DDDs/100 persons/day during 2009--2012. The per capita amount of antibacterials decreased from 980 yu- an in 2009 to 641 yuan in 2012. Average hospitalization stay decreased from 19.0 d in 2009 to 14.2 d in 2012. The ratio of antibac- terials decreased from 69.7% in 2009 to 50.0% in 2012. CONCLUSIONS： The interventions have obtained obvious effect. There sill are unreasonable aspects in specific type. More targeted intervention measures should be developed in the future due to deficien- cy so as to promote standard and reasonable use of antibacterials.