Estado actual y perspectivas futuras del trasplante de hepatocitos |
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Authors: | Eugenia Pareja,Miriam Corté s,M. José Gó mez-Lechó n,Javier Maupoey,Fernando San Juan,Rafael Ló pez,Jose Mir |
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Affiliation: | 1. Unidad de Cirugía Hepato-Bilio-Pancreática y Trasplante Hepático, Hospital Universitario La Fe de Valencia, Valencia, España;2. Unidad de Terapia Celular Hepática, Hospital Universitario La Fe de Valencia, Valencia, España;3. Unidad de Cirugía Hepato-Bilio-Pancreática y Trasplante Hepático, King''s College Hospital, Institute of Liver Study, Londres, Reino Unido;4. Unidad de Hepatología Experimental, Centro de Investigación, Hospital Universitario La Fe de Valencia, Valencia, España |
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Abstract: | The imbalance between the number of potential beneficiaries and available organs, originates the search for new therapeutic alternatives, such as Hepatocyte transplantation (HT).Even though this is a treatment option for these patients, the lack of unanimity of criteria regarding indications and technique, different cryopreservation protocols, as well as the different methodology to assess the response to this therapy, highlights the need of a Consensus Conference to standardize criteria and consider future strategies to improve the technique and optimize the results.Our aim is to review and update the current state of hepatocyte transplantation, emphasizing the future research attempting to solve the problems and improve the results of this treatment. |
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Keywords: | Trasplante hepá tico Trasplante celular hepá tico Errores congé nitos del metabolismo Criopreservació n Preacondicionamiento hepá tico Cé lulas madre progenitoras Cé lulas madre pluripotentes inducidas. |
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