Bcl-2和Bax在皮肤血管瘤组织中的表达及意义

目的 探讨Bcl-2和Bax在皮肤血管瘤发生、发展及退化过程中的作用及意义.方法 采用免疫组织化学方法(S-P法)检测人皮肤血管瘤增生期、退化期及正常组织中Bcl-2和Bax的表达水平.结果 Bcl-2在增生期血管瘤内皮细胞的表达明显高于退化期血管瘤内皮细胞和正常皮肤组织血管内皮细胞(P＜0.01);Bcl-2在退化期血管瘤内皮细胞的表达与正常皮肤组织血管内皮细胞相比,差异无统计学意义(P＞0.05).Bax在退化期血管瘤内皮细胞的表达明显高于增生期血管瘤内皮细胞和正常皮肤组织血管内皮细胞(P＜0.01);Bax在增生期血管瘤内皮细胞的表达高于正常皮肤组织血管内皮细胞(P＜0.05).结论 Bcl-2和Bax参与了血管瘤的发生、发展和退化.Bcl-2通过抑制内皮细胞凋亡而促进血管瘤的增生.Bax通过诱导内皮细胞凋亡而促进血管瘤由增生向退化的转变.

Expression of Bcl-2 and Bax in different phases of human dermal hemagniomas

Objective To investigate the function of Bcl-2 and Bax in the pathogenesis,development and regression of human hemangiomas.Methods We examined the expression of Bcl-2 and Bax in proliferating versus involuting human hemangioma tissues and normal skin tissues using immunohistochemical technique.Results The expression of Bcl-2 in proliferating hemangiomas was significantly higher than that in involuting hemangiomas and normal skin tissues(P＜0.01).No significant difference was found between the expression of Bcl-2 in involuting hemangiomas and that in normal skin tissues(P＞0.05).The expression of Bax in involuting hemangiomas was significantly higher than that in proliferating hemangiomas and normal skin tissues(P＜0.01);the expression of Bax in proliferating hemangiomas was significantly higher than that in normal skin tissues(P＜0.05).Conclusion Bcl-2 and Bax participate in the development and involution of hemangioma,Bcl-2 plays a role in accelerating the proliferation of hemangioma by inhibiting the apoptosis of endothelial cells,and Bax promotes the switching from proliferation to involution in hemangiomas through inducing the apoptosis of endothelial cells.