| P物质对乙酰胆碱与多巴胺引起豚鼠胆囊平滑肌收缩效应的影响 |
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| 引用本文： | 黄玲荪,张天祥,李韶,田伟. P物质对乙酰胆碱与多巴胺引起豚鼠胆囊平滑肌收缩效应的影响[J]. 滨州医学院学报, 1991, 0(1) |
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| 作者姓名： | 黄玲荪 张天祥 李韶 田伟 |
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| 作者单位： | 滨州医学院生理学教研室，滨州医学院生理学教研室，滨州医学院生理学教研室，滨州医学院生理学教研室 |
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| 摘 要： | 作者采用豚鼠离体胆囊平滑肌条标本,观察P物质对乙酰胆碱、多巴胺引起的离体胆囊平滑肌收缩效应的影响。结果表明:①P物质可引起胆囊平滑肌收缩并呈剂量—效应依赖性。②阈上剂量P物质(4×10~(-7)M)可明显加强乙酰胆碱(10~(-5)～10~(-7)M)及多巴胺(10~(-3)M)引起的离体胆囊平滑肌条的收缩效应。由此启示:P物质作为一种兴奋性递质或(和)调制物(Modulater)可与乙酰胆碱和多巴胺共同参与胆囊平滑肌运动的调节。
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| 关 键 词： | P物质 乙酰胆碱 多巴胺 胆囊 平滑肌收缩 |
EFFECTS OF SUBSTANCE P ON THE CONTRACTION OF THE GALLBLADDER OF GUINEA-PIG INDUCED BY ACETYLCHOLINE AND DOPAMINE |
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| Huang Lingsun,et al. EFFECTS OF SUBSTANCE P ON THE CONTRACTION OF THE GALLBLADDER OF GUINEA-PIG INDUCED BY ACETYLCHOLINE AND DOPAMINE[J]. Journal of Binzhou Medical College, 1991, 0(1) |
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| Authors: | Huang Lingsun et al |
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| Abstract: | The purpose of this study was to observe the effects of substance P (SP) on the contraction of gallbladder of guinea-pig induced by acetylcholine (Ach) and dopamine (DA) in vitro. The results were as follows: (1)SP could stimulate contraction of gallbladder strip in a doseresponse way. (2)SP could enhance the gallbladder contraction induced by Ach and DA. Our results suggest that SP as an excitatory transmitter and/or modulater might regulate the gallbladder motility with Ach and DA. |
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| Keywords: | substance P acetyl choline dopamine gallbladder smooth muscle contraction |
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