首页 | 本学科首页   官方微博 | 高级检索  
检索        

国内口腔鳞癌患者肿瘤组织中Cyclin D1表达的meta分析
引用本文:陈双艳,吴曦,余和东.国内口腔鳞癌患者肿瘤组织中Cyclin D1表达的meta分析[J].口腔医学,2014,34(9):701-704.
作者姓名:陈双艳  吴曦  余和东
作者单位:1. 上海市浦东新区眼病牙病防治所口腔科2. 中国医科大学附属盛京医院口腔科3. 中国医科大学附属盛京医院
摘    要:目的 探讨Cyclin D1在国人口腔鳞状细胞癌中的表达及其临床意义。方法 检索中国期刊全文数据库、中国生物医学期刊引文数据库、中文科技期刊数据库、万方和中国生物医学文献数据库,收集2000—2013年国内公开发表的有关Cyclin D1和口腔鳞状细胞癌的文献,进行meta分析。结果 最终纳入12篇病例对照研究,其中口腔鳞状细胞癌组629例,口腔正常黏膜组227例;meta分析结果:Cyclin D1在国人口腔鳞状细胞癌中的阳性表达率平均为69%,OR值及95% CI为20.51[12.50,33.66],P<0.000 01;Cyclin D1与口腔鳞状细胞癌淋巴结转移(P<0.000 01)、临床分期T(P=0.01)均有相关性。结论 Cyclin D1的表达与国人口腔鳞状细胞癌的发生有关,可以考虑将其作为口腔鳞状细胞癌治疗和预后的辅助性检测指标。

关 键 词:口腔鳞状细胞癌  Cyclin  D1  meta分析  
收稿时间:2013-04-01

Meta analysis of the clinical and biological significance of Cyclin D1 expression in oral squamous cell carcinoma of Chinese
Abstract:Objective  To explore Cyclin D1 expression in oral squamous cell carcinoma of Chinese people and its clinical significance.Methods  The CNKI,CMCI,VIP,CBM,Wanfang databases were searched electronically. The literature concerning Cyclin D1 and domestic oral squamous cell carcinoma from 2000 to 2013 were included for Meta analysis. Results  A total of 12 case control studies were carried out,involving 629 cases of oral squamous cell carcinoma and 227 cases of normal oral mucosa. The meta analysis results showed that the average positive expression rate of Cyclin D1 in oral squamous cell carcinoma of Chinese people was 69%,and the OR value was 20.51 with 95% confidence interval [CI]12.50 to 33.66,P<0.000 01 ; Cyclin D1 was correlated with node metastasis (P<0.000 01) and clinical stage T (P=0.01) of oral squamous cell carcinoma lymph. Conclusions Cyclin D1 expression is related to the occurrence of oral squamous cell carcinoma of Chinese people,which can be considered as the auxiliary detection index in treatment of oral squamous cell carcinoma and its prognosis.
Keywords:oral squamous cell carcinoma  Cyclin D1  meta-analysis  
点击此处可从《口腔医学》浏览原始摘要信息
点击此处可从《口腔医学》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号