急诊定量分级诊断在急性苯丙胺类药物过量患者中的临床应用价值

目的了解急性苯丙胺类兴奋剂中毒患者机体儿茶酚胺等血清学指标的变化,比较上述指标与急诊定量分级策略在对ATS中毒患者临床病情判断上的价值。方法收集我院急诊就诊88例患者,根据传统分级方法将其分为轻度、中度、重度3类,分别于就诊时采集患者外周静脉血,采用胶体金法检测肾上腺素、去甲肾上腺素、多巴胺、β-内啡肽浓度。根据我们之前制定的定量分级标准对此88例患者病情重新分级,观察患者治疗转归与血清学检测、定量分级标准之间的相关性。结果传统分级方法的3组患者好转率均低于定量分级方法,且血清肾上腺素、去甲肾上腺素、多巴胺、β-内啡肽的浓度无统计学意义。结论急诊定量分级诊断指导急性ATS中毒患者的病情评估和治疗意义优于血清学指标判断。

THE CLINICAL VALUE OF QUANTIFY INDEX FOR PATIENTS RECEIVED AMPHETAMINE -TYPE STIMULANTS IN EMERGENCY ROOM

Objective To study the level of catecholamine in ATS patients and evaluate whether those blood indicator is better than quantify index on the problem of clinical condition judgment. Methods We included 88 ea- ses patients from June 2009 to December 2011, and divided those patients into groups ： mild, moderate and severe in- toxication according to the traditional method. All patients were received IV and blood samples were collected for measurement of epinephrine, norepinephrine, dopamine and beta endorphin. Patients were still under evaluated base on quantify index in order to observed the prognosis and relationship of blood sample and the score. Results Im- provement rate from traditional method was lower than quantify index and there is no statistical significance of eate- cholamine and endorphin during groups. Conclusion For evaluation clinical condition and treatment, quantify index in better than level of catecholamine and endorphin in blood samle.