丙泊酚靶控输注和人工控制输注用于颅内动脉瘤介入治疗的比较

目的比较丙泊酚靶控输注（TCI）和人工控制输注（MCI）在颅内动脉瘤介入治疗术中麻醉效果、对呼吸循环功能及不良反应发生的影响。方法20例颅内动脉瘤患者。随机分为两组：M组采用丙泊酚MCI；T组采用丙泊酚TCI。分别记录麻醉效果，诱导与苏醒时间，丙泊酚总用量，监测不同时间点的血压（BP），心率（HR），血氧饱和度（SpO2）。记录术中体动、舌后坠、术后不良反应例数。结果两组患者麻醉与苏醒时间差异无显著性（P〉0．05），丙泊酚总用量T组明显大于M组（P〈0．05），T组麻醉效果优于M组（P〈0．05）。丙泊酚诱导后血压下降程度M组大于T组（P〈0．05），术中出现体动及术后不良反应例数M组多于T组（P〈0．05）。结论丙泊酚靶控输注用于颅内动脉瘤介入治疗优于丙泊酚人工控制输注。

Comparison of target controlled infusion or manually controlled infusion of propofol in embolization of intracranial aneurysms

Objective To compare the anesthesia qualities,hemodynamics,respiration and adverse reactions of target controlled infusion(TCI) of propofol with that of manually controlled infusion(MCI) in embolizing intracranial aneurysms(ICA).Methods Twenty patients undergoing embolized therapy were randomly divided into two groups: group MCI and group TCI.Anesthesia qualities,time to loss consciousness,recovery time,and the dosages of propofol were recorded as well as blood pressure,heart rate,SpO2 at different time in operation,Cases of restless moving in operation,glossocoma,nausea and vomiting after operation were also recoded.Results There were no significant differences in time to loss consciousness and recovery time between the two groups(P>0.05).Total dose of propofol in group TCI was higher than that in group MCI(P<0.05).The anesthetic efficacy in group TCI was better than that in group MCI.Blood pressure in group MCI decreased more significantly than that in group TCI(P<0.05).There were more cases of restless moving in operation in group MCI than that in group TCI(P<0.05).Conclusion The better anesthetic efficacy and fewer adverse reactions of TCI compared with MCI of propofol in embolization of ICA.