雌激素提高皮瓣存活面积的实验性研究

目的研究不同剂量雌激素对皮瓣存活面积的影响,并探讨其作用机制。方法新西兰白兔30只,随机分为A、B、O三组。在兔背作超长型皮瓣,其蒂部注射雌激素,三组间剂量不同。术后检测皮瓣血管内皮生长因子（VEGF）、一氧化氮（NO）、皮瓣存活面积（S）等指标。结果A组、B组皮瓣的NO、VEGF、S较O组增加;皮瓣存活面积S与VEGF表达、NO含量之间呈正相关。结论雌激素处理可使皮瓣VEGF表达上调、NO含量增加。

Experimental study of estrogen in increasing the flap survival area

Objective To study the effects of estrogen on flap survival, and investigate the invovled mechanism and regularity. Methods Thirty rabbits were divided radomly into three groups,which named Group A, Group B and group O. Group O was the control group. A random pattern flap was harvested on every rabbit＇ s back. Group A, Group B received subdermal estrogen injection of various doses. Postoperation, detected VEGF, NO and the survival area of every flap. Results The flap survival area, NO content, expression of VEGF in Group A and Group B increased compared with group O;The survival area of skin flap was highly related to VEGF,NO through linear regression analysis. Conclusion Estrogen injection can increase the VEGF of expression and NO content of flaps.