Antioxidant effects of insulin-like growth factor-I (IGF-I) in rats with advanced liver cirrhosis |
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| Authors: | María García-Fernández Inma Castilla-Cortázar Iñigo Navarro Juan Enrique Puche Alberto Castilla Amelia Díaz Casares Encarna Clavijo Salvador González-Barón |
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| Affiliation: | 1.Department of Physiology,School of Medicine, University of Navarra,Pamplona,Spain;2.Department of Human Physiology,School of Medicine, University of Málaga,Spain;3.Department of Physiology,School of Medicine, University of San Pablo-CEU,Madrid,Spain;4.Department of Chemistry,School of Medicine, University of Navarra,Pamplona,Spain;5.Department of Internal Medicine,Hospital Sierrallana,Torrelavega. Cantabria,Spain;6.Department of Microbiology,School of Medicine, University of Málaga,Spain |
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| Abstract: | Background The exogenous administration of Insulin-like Growth Factor-I (IGF-I) induces hepatoprotective and antifibrogenic actions in experimental liver cirrhosis. To better understand the possible pathways behind the beneficial effect of IGF-I, the aim of this work was to investigate severe parameters involved in oxidative damage in hepatic tissue from cirrhotic animals treated with IGF-I (2 μg. 100 g-1. day-1). Iron and copper play an important role in oxidative mechanisms, producing the deleterious hydroxyl radical (*OH) that peroxides lipid membranes and damages DNA. Myeloperoxidase (MPO) and nitric oxide (NO) are known sources of free radicals and induce reduction of ferritin-Fe3+ into free Fe2+, contributing to oxidative damage. |
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