The chromosomal complements of cleaved human embryos resulting from in vitro fertilization |
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| Authors: | Sai MA Dagmar K. Kalousek Christo Zouves Basil Ho Yuen Victor Gomel Young S. Moon |
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| Affiliation: | (1) Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Shaughnessy Hospital, Vacouver, British Columbia, Canada;(2) Department of Pathology, Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada;(3) Garce Hospital, Room 2H30, 4490 Oak Street, V6H 3V5 Vancouver, British Columbia, Canada |
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| Abstract: | ![]()
Chromosome preparations were made from 25 cleaved abnormal human embryos at the two-to eight-cell stage after in vitro fertilization. Morphologically, these embryos showed either variable degrees of degeneration or an abnormal number of pronuclei before first cleavage. Among 14 successfully karyotyped embryos, only 3 had a normal chromosomal complement. Eleven showed chromosomal abnormalities, including triploidy, hapioidy, and mosaicism. This finding documents a high incldence of chromosomal errors in morphologically abnormal early preimplantation embryos. |
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| Keywords: | triploidy haploidy parthenogenesis mosaicism degeneration abnormal number of pronuclei |
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