磁铁压迫吻合术治疗肠梗阻动物实验研究

目的:为了开展磁铁压迫吻合术治疗不宜手术的肠梗阻,开发系列磁铁并进行了深入研究.方法:雌、雄性杂种犬9只;钐钴(Samarium-Cobalt)磁铁2块,直径15～20 mm,厚3～5 mm,2 300～3 200G.肌内注射麻醉.切开回肠末端,将一磁铁块置入其近侧回肠内(子磁铁);将另一磁铁块置入结肠内(母磁铁).结扎子母磁铁之间的回肠,致完全梗阻.摄腹平片,观察2块磁铁之间的距离、在腹部的位置、自肛门排出的时间、排出后实验犬进食情况;活体观察内瘘的完整性、蠕动情况;组织学观察压迫吻合内瘘标本.结果:腹平片示两磁铁块之间的缝隙从1.5 mm缩小至0.5mm.2 300～2 770 G组磁铁排出时间为术后6～14 d.解剖学观察:磁铁压迫吻合内瘘完整;组织学观察:内瘘呈坏死层、肉芽层及瘢痕层特异性结构,慢性损伤后修复性改变.长期存活犬能正常饮食.3 200 G组磁铁排出时间为术后3～4 d,实验犬因肠穿孔而死亡.结论:磁铁压迫吻合术治疗犬肠梗阻,2 300～2 770 G的磁铁为安全治疗范围.有望在中国应用于临床.

Study on treatment of bowel obstruction by magnetic compression anastomosis in hybid dogs

Objective: To make magnetic compression anastomosis between the small intestines as a novel treatment, using the advances in interventional radiology. Methods: One magnet was put into the ileum of an adult dog, another magnet was put into the colon of the dog, the ileum between the two magnets was ligatured causing a complete obstruction of the small intestine. Two magnets were immediately attracted towards each other transmurally, so that the walls of intestine were compressed together. Results: Two magnet...