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| 洁源胶囊对大鼠肾衰模型的防治作用机理研究 | |
| 引用本文： | 赵晓琳,昌平,周毅,邓虹珠.洁源胶囊对大鼠肾衰模型的防治作用机理研究[J].中药新药与临床药理,2007,18(5):361-364. |
| 作者姓名： | 赵晓琳 昌平 周毅 邓虹珠 |
| 作者单位： | 1. 解放军第323医院,西安,710056 2. 兰州军区总医院药材科,兰州,730050 3. 南方医科大学中医药学院,广州,510515 |
| 摘 要： | 目的探讨洁源胶囊对5/6肾切除致慢性肾功能衰竭大鼠的作用机理。方法通过切除大鼠5/6肾脏建立慢性肾功能衰竭大鼠模型,观察给药后血尿素氮(BUN)、肌酐(Scr)、血液学及生化、肾组织学的变化。结果洁源胶囊能显著降低血BUN、Scr,改善电解质水平,改善肾性贫血,减轻肾组织的病理变化。结论洁源胶囊能够减轻肾切除致大鼠慢性肾衰症状并延缓肾衰进程。 |
| 关 键 词： | 洁源胶囊 慢性肾衰 5/6肾切除 尿素氮 肌酐 |
| 文章编号： | 1003-9783（2007）05-0361-04 |
| 收稿时间： | 2007-03-21 |
| 修稿时间： | 2007年3月21日 |
Curative Mechanism of Jieyuan Capsule on Rats Renal Failure Induced by 5/6 Nephrectomy |
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| ZHAO Xiaolin,CHANG Ping,ZHOU Yi,DENG Hongzhu.Curative Mechanism of Jieyuan Capsule on Rats Renal Failure Induced by 5/6 Nephrectomy[J].Traditional Chinese Drug Research & Clinical Pharmacology,2007,18(5):361-364. | |
| Authors: | ZHAO Xiaolin CHANG Ping ZHOU Yi DENG Hongzhu |
| Abstract: | Objective To explore the curative mechanism of Jieyuan (JY) Capsule on rats renal failure induced by 5/ 6 nephrectomy. Methods Chronic renal failure (CRF) rat models induced by 5/6 nephrectomy were administered with JY Capsule. The serum levels of blood urea nitrogen (BUN) and serum creatinine (Scr),hematological and biochemical indexes,and renal histological features were observed. Results JY Capsule reduced levels of BUN and Scr,ameliorated the electrolyte,increased the number of red blood cell and hemoglobin content,and alleviated pathological changes of the kidney tissue. Conclusion JY Capsule can relieve the rat CRF symptoms and postpone the progress of CRF. |
| Keywords: | Jieyuan Capsule Chronic renal failure 5/6 nephrectomy Blood urea nitrogen Serum creatinine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |