105例妊娠期肝内胆汁淤积症临床分析

目的探讨妊娠期肝内胆汁淤积症(ICP)对母儿的不良影响.方法对105例ICP病人进行回顾性分析.结果与孕28w以后出现搔瘁的患者比较,孕28w以前出现搔瘁的患者的胆汁酸、转氨酶及胆红素值显著性升高(P＜0.05),孕妇各种妊娠结局、围生儿结局的发生率及羊水粪染率显著性升高(P＜0.05).结论ICP易引起早产、胎儿宫内窘迫、胎儿突死官内及母亲产后出血,病人发病时间越早,围产儿预后越差,母亲产后出血发生率及羊水粪染率越高.

Clinical analysis of 105 cases of intrahepatic cholestasis of pregnancy

Objective: To evaluate poor outcomes in the mother and child in intrahepatic cholestasis of pregnancy. Methods: 80 patients with ICP were studied retrospectively. Results: Compared with bile acid, bilirubin and transaminase level of icp patients in the presence of itching after 28 weeks, those of icp patients with itching before 28 significantly increase ( P <0.05), moreover, the incidence of pregnant and fetal outcomes and the rate of meconium staining also significantly increase ( P <0.05). Conclusions: ICP poses significant risk to premature delivery, fetal distress, sudden death and postpartum hemorrhage. The ealier the disease comes on, the worse the fetal prognosis becomes, the higher the rates of postpartum hemorrhage and meconium staining in amniotic fluid rise.