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水通道蛋白与多囊卵巢综合征发病机制的研究进展
引用本文:黄诗雅,温麒丹,李娟,马红霞. 水通道蛋白与多囊卵巢综合征发病机制的研究进展[J]. 国际生殖健康/计划生育杂志, 2018, 37(5): 409-413
作者姓名:黄诗雅  温麒丹  李娟  马红霞
作者单位:510120 广州医科大学附属第一医院中医科
摘    要:
水通道蛋白(aquaporins,AQPs)是一组跨膜蛋白,有13种AQPs(AQP0~AQP12)在哺乳动物生殖系统中表达,分为水通道亚族、水-甘油通道亚族和超级水通道亚族。AQPs能够通过细胞膜运输水,而水-甘油通道亚族除对水的通透性外,对甘油和尿素等中性小分子也有通透性。多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者中,至少存在3种AQPs表达异常,主要包括AQP7、AQP8和AQP9表达障碍。PCOS患者中AQPs表达水平的改变及其功能障碍,可能影响卵泡形成和卵泡闭锁,并且与脂肪代谢有密切的联系。AQP1~4,AQP8和AQP9与PCOS卵泡生长关系密切,而AQP7及AQP9的下调在PCOS脂肪代谢紊乱的发病机制中起着重要作用。通过了解AQPs的功能和表达与PCOS症状之间的关系,探索潜在的、新的以AQPs为导向的PCOS治疗方法。

关 键 词:多囊卵巢综合征  水孔蛋白质类  卵泡  胰岛素抗药性  治疗  
收稿时间:2018-06-14

Aquaporins and Polycystic Ovary Syndrome: A Review
HUANG Shi-ya,WEN Qi-dan,LI Juan,MA Hong-xia. Aquaporins and Polycystic Ovary Syndrome: A Review[J]. Journla of International Reproductive Health/Family Planning, 2018, 37(5): 409-413
Authors:HUANG Shi-ya  WEN Qi-dan  LI Juan  MA Hong-xia
Affiliation:Department of Traditional Chinese Medicine,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China
Abstract:
Aquaporins (AQPs), a group of transmembrane proteins, have 13 types of aquaporins (AQP0-AQP12) expressed in mammalian reproductive system. They can be divided into three subfamilies, including water channel subfamily, water-glycerol channel subfamily and super aqua channel subfamily. AQPs can transport water through the cell membrane, while the AQPs of water-glycerol channel subfamily can also transport neutral molecules such as glycerol. The expressions of at least three AQPs (AQP7, AQP8, AQP9) are abnormal in women with polycystic ovary syndrome (PCOS), which may affect folliculogenesis and follicular atresia, as well as adipose metabolism. AQP1-4 and AQP8-9 are closely related to the growth of follicles. The down-regulations of AQP7 and AQP9 are factors of adipose metabolism disorder in PCOS. This paper reviews the function of AQPs and AQPs expression related with PCOS, which may provide new therapeutic opportunities for PCOS.
Keywords:Polycystic ovary syndrome  Aquaporins  Ovarian follicle;Insulin resistance;Therapy  
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