生长激素和脱氢表雄酮在卵巢低反应患者的临床应用及其研究进展

卵巢低反应（POR）是指在控制性超促排卵（COH）过程中,卵巢对促性腺激素（Gn）刺激反应不佳的病理状态。随着社会发展,女性生育年龄普遍推迟,以及“二孩政策”的放开,目前高龄欲生育的女性逐年增加。而年龄大于40岁的女性,POR发生率较高,如何解决这部分患者的生育问题,不仅是我国今后辅助生殖领域的热点话题,也是国际性的研究趋势。目前临床上常使用一些药物预处理来改善患者治疗结局。本文就近促排卵周期前,临床上最常用的预治疗药物生长激素和脱氢表雄酮的研究进展进行综述。

The Application of Growth Hormone and Dehydroepiandrosterone in Patients with Poor Ovarian Response: A Review

Poor ovarian response (POR) is the pathological state in which the response of ovaries to gonadotropin (Gn) stimulation is poor during the controlled superovulation (COH). With the development of society, women′s childbearing age postponed generally, and the "two-child policy" liberalized, the number of advanced women who want to have children has been increasing year by year. It is true that the incidence of POR is higher in women aged over 40 years. How to solve the fertility problem of POR patients is a hot topic in the field of assisted reproduction. Growth hormone and dehydroepiandrosterone have been tried as a pretreatment of Gn in those POR patients, which may improve the clinical outcomes of assisted reproductive technology. This article reviews the research progress of the clinical application of growth hormone and dehydroepiandrosterone in POR patients as a pretreatment of Gn.