| VSIG4在恶性肿瘤诊治中的研究进展 |
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| 引用本文： | 许世莹,黄煜庆,郑国湾.VSIG4在恶性肿瘤诊治中的研究进展[J].肿瘤学杂志,2021,27(2):148-152. |
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| 作者姓名： | 许世莹 黄煜庆 郑国湾 |
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| 作者单位： | 浙江中医药大学第二临床医学院;杭州市萧山区第一人民医院;浙江省人民医院 |
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| 摘 要： | VSIG4(the protein V-set and immune globulin domain-containing 4)是一种与巨噬细胞蛋白质相关的新的B7相关免疫球蛋白的Ⅰ型跨膜蛋白,具有抑制T细胞活化的能力,也被称为CRIg(免疫球蛋白超家族)和Z39Ig,在病原体识别和清除中起关键作用。恶性肿瘤中,VSIG4的表达及VSIG4阳性T细胞的增加可能预示更高的侵袭性和复发风险。全文就VSIG4与各肿瘤间的关系作一简要概述,为VSIG4与恶性肿瘤诊治提供参考。
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| 关 键 词： | VSIG4 新型B7相关免疫球蛋白 恶性肿瘤 治疗靶点 |
| 收稿时间： | 2020/8/26 0:00:00 |
Research Progress of VSIG4 in Diagnosis and Treatment of Malignant Tumors |
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| XU Shi-ying,HUANG Yu-qing,ZHENG Guo-wan,WANG Jia-feng,JIANG Lie-hao,GE Ming-hua.Research Progress of VSIG4 in Diagnosis and Treatment of Malignant Tumors[J].Journal of Oncology,2021,27(2):148-152. |
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| Authors: | XU Shi-ying HUANG Yu-qing ZHENG Guo-wan WANG Jia-feng JIANG Lie-hao GE Ming-hua |
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| Institution: | (Second Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou 310053,China;The First People’s Hospital of Xiaoshan District,Hangzhou 311200,China;Zhejiang Provincial People’s Hospital,Hangzhou 310014,China) |
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| Abstract: | The protein V-set and immunoglobulin domain containing protein 4(VSIG4),also known as CRIg and Z39Ig,is a novel typeⅠtransmembrane protein of B7-related immunoglobulin superfamily and a negative regulator of T cell activation,which plays a key role in pathogen identification and clearance.In malignant tumors,the expression of VSIG4 and the increase of VSIG4 positive T cells may indicate higher aggressiveness and greater risk of recurrence.This article gives a brief overview of the relationship between VSIG4 and various cancer,and provides references for application of VSIG4 in the diagnosis and treatment of malignant tumors. |
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| Keywords: | VSIG4 novel B7 family-related immune globulin malignant tumor therapeutic target |
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