精子代谢与男性不育的相关性研究进展

精子发生和成熟中涉及到多种与代谢相关的过程，任何一种代谢异常都可引起精子活动力、受精能力等受损，最终导致男性不育的发生，如精子中活性氧簇过度产生引起的氧化应激反应，损害了精子的运动和获能；在临床上，男性不育症患者的精浆与正常男性相比，其代谢物成分表现出明显的变化，也可反映精子发育和成熟过程的异常，并间接表明这可能与男性不育相关。本文从精子代谢的相关途径、精子代谢组学检测与精子活动力及临床男性不育症的相关性等方面进行综述。

Sperm Metabolism and Male Infertility

A variety of metabolism-related courses are involved in spermatogenesis and sperm maturation. Any metabolic abnormality will damage the sperm motility and fertilization, which eventually leads to male infertility. For example, the oxidative stress caused by the excessive production of reactive oxygen in sperm impairs the sperm motility and capacitation. In clinic, the metabolic profiling of seminal plasma in the infertile patients was different from that in the normal male, suggesting the abnormality of sperm development and maturation. This study indirectly showed that there is a potential relevancy between the abnormal metabolism of sperm and male infertility. In this review, we discussed sperm metabolism and the related pathways, sperm metabonomics and tests, the relationship between sperm metabolism and sperm motility, and male infertility.