| 免疫检查点抑制剂心脏毒性的临床热点与争议 |
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| 引用本文： | 王阿曼,方凤奇,刘莹,夏云龙,刘基巍.免疫检查点抑制剂心脏毒性的临床热点与争议[J].中国心血管病研究杂志,2021,19(2). |
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| 作者姓名： | 王阿曼 方凤奇 刘莹 夏云龙 刘基巍 |
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| 作者单位： | 大连医科大学附属第一医院,大连医科大学附属第一医院,大连医科大学附属第一医院,大连医科大学附属第一医院,大连医科大学附属第一医院 |
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| 摘 要： | 免疫检查点抑制剂(ICIs)使多种晚期恶性肿瘤的治疗模式开启了新变革。尽管免疫检查点抑制剂相关心脏毒性较为罕见,但致死性极高。以往研究中免疫检查点抑制剂心脏毒性的发生率被低估。本综述聚焦于目前免疫检查点抑制剂心脏毒性方面的研究进展,包括流行病学、评估、诊断、治疗和预后等。接受ICIs治疗者的最佳肿瘤心脏病管理模式仍面临诸多挑战。
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| 关 键 词： | 免疫检查点抑制剂 心脏毒性 诊断 治疗 |
| 收稿时间： | 2020/7/18 0:00:00 |
| 修稿时间： | 2021/1/15 0:00:00 |
Clinical focused issues and controversies of cardiotoxicity of immune checkpoint inhibitors |
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| fang feng qi,liu ying,xia yun long and liu ji wei.Clinical focused issues and controversies of cardiotoxicity of immune checkpoint inhibitors[J].Chinese Journal of Cardiovascular Review,2021,19(2). |
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| Authors: | fang feng qi liu ying xia yun long and liu ji wei |
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| Institution: | The First Affiliated Hospital of Dalian Medical University,The First Affiliated Hospital of Dalian Medical University,The First Affiliated Hospital of Dalian Medical University,The First Affiliated Hospital of Dalian Medical University |
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| Abstract: | Immune checkpoint inhibitors (ICIs) have started revolutionizing the treatment of various advanced cancers advanced malignancies. Although ICIs-related cardiotoxicity is rare, it has significant relevance due to high mortality rates. Cardiotoxicity has largely been underestimated in previous studies of toxicity of ICIs. This review focuses on current knowledge about ICIs-related cardiotoxicity, including the incidence, assessment, diagnosis, treatment, prevention and outcome. Future challenges are depicted for optimum cardio-oncology care of patients receiving ICIs therapy. |
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| Keywords: | immune checkpoint inhibitors cardiotoxicity diagnosis treatment |
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