长链非编码RNA高表达与子宫内膜癌病理特征和预后关系的Meta分析

目的：分析长链非编码RNA（lncRNA）高表达与子宫内膜癌病理特征及预后的相关性，系统评价其对子宫内膜癌患者预后的预测价值。方法：计算机检索Pubmed、Embase、Web of Science、中国知网、万方和维普等数据库相关文献，检索时间为建库至2017年10月9日，根据制定的纳入和排除标准选择文献并进行质量评价，提取子宫内膜癌患者的病理特征和生存相关数据。应用Revman 5.3及Stata 12.0统计软件对数据进行合并分析。结果：共纳入9篇文献（其中1篇中文、8篇英文），包含775例子宫内膜癌患者。Meta分析结果显示，lncRNAs高表达与国际妇产科联盟（FIGO）分期（OR=2.41，95%CI：1.11～5.25，P=0.03）、组织学分级（OR=2.01，95%CI：1.19～3.41，P=0.009）、肌层浸润（OR=2.29，95%CI：1.16～4.51，P=0.02）及淋巴结转移（OR=4.00，95%CI：2.40～6.66，P＜0.000 01）均显著相关；与孕激素受体（PR）及雌激素受体（ER）阳性表达均无关（P＞0.05）；与lncRNAs低表达组比较，高表达组患者OS较短（HR=2.43， 95%CI：1.55～3.80）；亚组分析HOTAIR高表达与OS相关（HR=3.73，95%CI：1.21～11.49）。结论：lncRNAs高表达对子宫内膜癌患者的预后具有重要预测价值。lncRNAs表达越高、临床分期及组织学分级越高、肌层浸润越深，淋巴结转移风险亦增加，总生存期缩短，预后越差。

The Relationship between Long Non-Coding RNA Overexpression and Clinicopathological Features and Prognosis in Endometrial Cancer: A Meta Analysis

Objective：To analyze the correlation between the high expression of lncRNAs and the pathological characteristics and prognosis of endometrial carcinoma, and systematically to evaluate its prognostic value in endometrial cancer. Methods: We searched the electronic databases such as Pubmed, Embase, Web of science, CNKI, Wan Fang, VIP from inception to October 9, 2017. Literature selection was performed according to inclusion and exclusion criteria, then quality assessment was carried out, and data was extracted. Revman 5.3 and stata 12.0 software were used for meta analysis. Results: 9 studies (1 Chinese, 8 English) and 775 endometrial cancer patients met the inclusion criteria. The results of meta-analysis showed that high expression of lncRNAs was associated with FIGO stage (OR=2.41, 95%CI: 1.11-5.25, P=0.03), histological grade (OR=2.01, 95%CI: 1.19-3.41, P=0.009), the myometrial invasion (OR=2.29, 95%CI: 1.16-4.51, P=0.02) and lymph node metastasis (OR=4.00, 95%CI: 2.40-6.66, P＜0.000 01), lncRNAs had nothing to do with the PR and ER positive expression (P＞0.05). Patients with high expression of lncRNAs had a shorter OS compared with low expression (HR=2.43, 95%CI: 1.55-3.80). In a subgroup analysis, HOTAIR correlated with OS (HR=3.73, 95%CI: 1.21-11.49). Conclusions: LncRNAs overexpression has an important predictive value for prognosis in endometrial cancer patients. The higher the expression of LncRNAs, the higher the clinical stage and histological grade, the deeper the infiltration of myometrium and the increased risk of lymph node metastasis, the shorter the os and the worse the prognosis.