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| DJ-1与子痫前期关系的研究进展 | |
| 引用本文： | 杨婷婷,颜建英. DJ-1与子痫前期关系的研究进展[J]. 国际妇产科学杂志, 2018, 45(4): 373-377 |
| 作者姓名： | 杨婷婷 颜建英 |
| 作者单位： | 350000 福州，福建医科大学附属福建省妇幼保健院妇产科 |
| 基金项目： | 福建省科技计划引导性项目（2016Y0060），福建省医学创新课题（2017-CX-11） |
| 摘 要： | DJ-1又名帕金森病蛋白7（ Parkinson disease protein 7，PARK7）属于ThiJ/PfpI/DJ-1超家族，DJ-1是一种抗氧化剂，抗氧化应激是其主要功能，近年研究发现DJ-1在子痫前期（preeclampsia，PE）患者胎盘组织中表达水平升高，推测 DJ-1通过氧化应激途径参与子痫前期的发生发展。子痫前期是妊娠期特有疾病，是导致孕产妇和新生儿发病率和死亡率增高的主要原因。但子痫前期的病因和发病机制尚在研究探讨，其中氧化应激损伤参与子痫前期的发生发展是其中研究的一个热点，就DJ-1在子痫前期中的作用机制进行综述。 |
| 关 键 词： | 先兆子痫 氧化性应激 活性氧 DJ-1 |
| 收稿时间： | 2018-03-19 |
Research Progress of the Relationship between DJ-1 and Preeclampsia |
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| YANG Ting-ting,YAN Jian-ying. Research Progress of the Relationship between DJ-1 and Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2018, 45(4): 373-377 | |
| Authors: | YANG Ting-ting YAN Jian-ying |
| Affiliation: | Department of Obstetrics and Gynecology，Fujian Provincial Maternity and Children Hospital，Affiliated Hospital of Fujian Medical University，Fuzhou 350000，China |
| Abstract: | DJ-1, also known as Parkinson disease protein 7 (PARK7), belongs to the ThiJ/PfpI/DJ-1 superfamily of PARK7. DJ-1 is an antioxidant and antioxidant stress is its main function. In recent years, it is speculated that DJ-1 is involved in the development of preeclampsia through oxidative stress pathway. Preeclampsia (PE) is a special disease of pregnancy and a leading cause of both maternal and neonatal morbidity and mortality. However the pathophysiological mechanisms of PE remain poorly known, and the role of oxidative stress injury in the development of preeclampsia is a hot topic. The view summarized the mechanism of DJ-1 in preeclampsia. |
| Keywords: | Pre-eclampsia Oxidative stress Reactive oxygen species DJ-1 |
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