杜仲颗粒联合拉贝洛尔治疗妊娠期高血压的疗效观察

目的探讨杜仲颗粒联合盐酸拉贝洛尔注射液治疗妊娠期高血压的临床疗效。方法选取2017年3月—2019年10月郑州市妇幼保健院收治的80例妊娠期高血压患者,根据随机数字表法将所有患者分为对照组和治疗组,每组各40例。对照组静脉滴注盐酸拉贝洛尔注射液,将100 mg盐酸拉贝洛尔注射液溶于250 mL生理盐水中,1次/d。治疗组在对照组的基础上温水冲服杜仲颗粒,5g/次,2次/d。两组患者连续治疗2周。观察两组临床疗效,比较两组的收缩压、舒张压、血流动力学指标、不良妊娠结局。结果治疗后,治疗组的总有效率为87.50%,高于对照组的65.00%,组间比较差异有统计学意义(P<0.05)。治疗后,两组收缩压、舒张压较治疗前降低(P<0.05);且治疗组收缩压、舒张压较对照组低(P<0.05)。治疗后,两组心脏指数较治疗前升高,外周阻力较治疗前降低(P<0.05);治疗后治疗组心脏指数较对照组高,外周阻力较对照组低(P<0.05)。治疗后,治疗组患者的不良妊娠结局发生率为12.50%,低于对照组患者的32.50%(P<0.05)结论杜仲颗粒联合盐酸拉贝洛尔注射液治疗妊娠期高血压具有较好的临床疗效,可有效改善患者血流动力学,降低血压和不良妊娠结局发生率,且安全性较好。

Clinical observation of Duzhong Granules combined with labetalol in treatment of hypertensive disorder complicating pregnancy

Objective To investigate clinical efficacy of Duzhong Granules combined with Labetalol Hydrochloride Injection in treatment of hypertensive disorder complicating pregnancy. Methods Patients (80 cases) with hypertensive disorder complicating pregnancy in Women & Infants Hospital of Zhengzhou from March 2017 to October 2019 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were iv administered with Labetalol Hydrochloride Injection, 100 mg added into normal saline 250 mL, once daily. Patients in the treatment group were po administered with Duzhong Granules on the basis of the control group, 5 g/time, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and systolic blood pressure, diastolic blood pressure, hemodynamic indicators, and adverse pregnancy outcomes in two groups were compared. Results After treatment, the total effective rate of the treatment group was 87.50%, which was higher than 65.00% of the control group (P<0.05). After treatment, the systolic blood pressure and diastolic blood pressure of two groups were decreased (P<0.05), and these indexes of the treatment group were lower than those of the control group (P<0.05). After treatment, the cardiac index of two groups was increased, but the peripheral resistance was decreased (P<0.05). After treatment, the cardiac index of the treatment group was higher than that of the control group, but the peripheral resistance was lower than that of the control group (P<0.05). After treatment, the incidence of adverse pregnancy outcomes in the treatment group was 12.50%, which was lower than 32.50% in the control group (P<0.05). Conclusion Duzhong Granules combined with Labetalol Hydrochloride Injection has clinical effect in treatment of hypertensive disorder complicating pregnancy, can effectively improve the hemodynamics, reduce the blood pressure and the incidence of adverse pregnancy outcomes, with good safety.