| 鲜生地(冻干粉)对肝损伤模型大鼠肠生物屏障的影响 |
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| 引用本文： | 李晨龙,贾建伟,李秋伟.鲜生地(冻干粉)对肝损伤模型大鼠肠生物屏障的影响[J].天津中医药,2014,31(3):165-167. |
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| 作者姓名： | 李晨龙 贾建伟 李秋伟 |
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| 作者单位： | 天津中医药大学, 天津 300193;天津市第二人民医院中西医结合Ⅰ科, 天津 300192;天津市第二人民医院中西医结合Ⅰ科, 天津 300192 |
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| 基金项目： | 天津市卫生局科技基金项目（2010kz12）. |
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| 摘 要： | 目的]探讨鲜生地(冻干粉)对肝损伤模型大鼠肠生物屏障的影响。方法]采用Pringle’s maneuver法制作大鼠肝缺血再灌注损伤模型。将64只实验大鼠随机分为假手术组、模型组、鲜生地(冻干粉)组及乳果糖组。观察大鼠粪便球杆菌比例、菌落培养,测定血清内毒素水平。结果]鲜生地组、乳果糖组粪便中益生菌增加,大肠杆菌减少,血清内毒素水平降低。结论]鲜生地能够调节肠道菌群,降低血内毒素水平,可能通过改善肠生物屏障,使肝细胞得到恢复。
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| 关 键 词： | 鲜生地 肝损伤 生物屏障 |
| 收稿时间： | 2013/9/15 0:00:00 |
Effect of fresh rehmannia (freeze-dried) on intestinal biological barrier in rats with liver injury |
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| LI Chen-long,JIA Jian-wei and LI Qiu-wei.Effect of fresh rehmannia (freeze-dried) on intestinal biological barrier in rats with liver injury[J].Tianjin Journal of Traditional Chin Medicine,2014,31(3):165-167. |
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| Authors: | LI Chen-long JIA Jian-wei and LI Qiu-wei |
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| Institution: | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Department of Integrated Chinese and Western Medicine (Division I), The Second People's Hospital of Tianjin, Tianjin 300192, China;Department of Integrated Chinese and Western Medicine (Division I), The Second People's Hospital of Tianjin, Tianjin 300192, China |
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| Abstract: | Objective] To explore the effect of fresh rehmannia (freeze-dried) on intestinal biological barrier in liver damaged rats. Methods] According to the method of Pringle's maneuver, hepatic ischemia reperfusion was induced in rats. The 64 rats were randomly divided into sham operation group, model group, fresh rehmannia (freeze-dried ) group and the lactulose group. We observed the proportion ratio of coccobacillus in rats' feces, cultured the bacterial colony and measured the level of endotoxin. Results] In fresh rehmannia group and lactulose group the probiotics was increased, escherichia coli was decreased and the level of endotoxin was decreased. Conclusion] Fresh rehmannia can regulate the intestinal flora, and reduce blood endotoxin level. It may improve the intestinal biological barrier and recover the liver cells. |
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| Keywords: | fresh rehmannia liver injury biological barrier |
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