GST-π和P-gp在大肠癌中的表达及意义

目的：研究大肠癌谷胱甘肽-巯基-转移酶-π（GST-π）和P-糖蛋白（P-gp）的表达情况及二者与大肠癌临床病理特征的关系。方法：应用免疫组织化学S-P法检测86例大肠癌组织和52例远端正常组织（距癌灶〉locm）GST-π和P—gp）的表达情况，并分析二者与大肠癌临床病理特征的关系。结果：大肠癌组织GST-π和P—gp）的阳性表达率均明显高于远端正常组织（P〈0．01，P〈0．05）。大肠癌组织P—gp表达与淋巴结转移有关，有淋巴结转移者P1p阳性表达率明显高于无淋巴转移者垆〈0．05）。大肠癌G跚、一丌和P—gp的表达呈正相关妒〈0．01）。结论：GST-π、P—gp）在大肠癌中的高表达可能与大肠癌原发性多药耐药有关，临床联合检测GST-π和P-gp可为制定合理的个体化化疗方案提供理论依据。

EXPRESSION OF GST-II AND P-GP IN COLORECTAL CANCERAND THEIR CLINICAL SIGNIFICANCES

Objective：To study the expression of glutathione-s-tmnsferase-n （GST-n） and P-glycoprotein （P-gp） in human colorectal cancer and their relationships with clinical pathological characteristics of colorectal cancer. Methods：S-P staining was used to detect the expression of GST-n and P-gp in 86 cases colorectal cancer and 52 cases distal nonnal tissue （〉 10crn from the cancer）. And the correlations between GST-π, P-gp expression and the clinical pathological characteristics of colorectal cancer were analyzed.Results：The positive expression rate of GST-π and P-gp in colorectal cancer were all significantly higher than that in distal normal tissues （P〈 0.01, P〈 0.05）. The expression of P-gp in colorectal cancer was related with lymph node metastasis： the positive expression rate of P-gp of patients with lymph node metastasis was significantly higher than that no lymph node metastasis （P〈 0.05）. There had positive correlation between GST-n and P-gp expression in colorectal cancer （P〈 0.01）. Conclusions： High expression of GST-π and P-gp in colorectal cancer may be associated with primary multidrug resistance of the cancer. Joint detection of GST-π and P-gp in clinic can provide theoretical basis for reasonable individual chemotherapy scheme.