急性肺损伤发病机制的研究进展

急性肺损伤（ALI）是临床常见的急危重症,病死率高,多年来对其发病机制进行了大量的研究。随着失控的炎症反应引发多器官功能紊乱综合征理论的出现,对ALI的认识转向对炎症发生、调控的认识,参与炎症的炎症细胞和细胞因子则成为研究的热点,这些细胞和细胞因子、炎症介质构成了ALI炎症反应和免疫调节的“细胞网络”和“细胞因子网络”在其发病过程中发挥重要作用,本文将对近年来的研究做一综述。

Advance in pathogenesis study of acute lung injury

Acute lung injury remains a major cause of morbidity and mortality in acute or seriously ill patients,and the pathogenesis of acute lung injury is not well understood though much work has done on it. Acute lung injury often occurs as a part of multiorgan dysfunction syndrome,the pathophysiology of which is driven by an aggressive inflammatory reaction. So it is well known that there are widespread inflammatory changes out of control throughout the lung, and many concerns are about the cells, cytokines and mediators of inflammation which are all involved in and play very important parts in the pathogenesis of acute lung injury. Here is a review on it.