阿托伐他汀钙片与通心络胶囊联用对颈动脉内膜中层厚度及炎症标志物的影响

目的探讨阿托伐他汀钙片与通心络胶囊联用对高脂血症并发颈动脉粥样硬化患者颈动脉内膜中层厚度及炎症标志物的影响。方法选取70例高脂血症并发颈动脉粥样硬化患者，随机分为治疗组和对照组，两组患者均予常规治疗。治疗组给予阿托伐他汀钙片20mg，睡前顿服；通心络胶囊每次4粒，3次／d。对照组单独给予阿托伐他汀钙片20mg，睡前顿服，两组疗程均为12周。治疗前、治疗12周后留取血标本作总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL—C）、甘油三酯（TG）等血脂分析以及高敏C反应蛋白（hs—CRP）、肿瘤坏死因子-α（TNF-α）水平测定，并通过颈动脉彩超测定颈动脉内膜中层厚度（IMT）。结果治疗12周后，TC、TG、LDL—C水OF均显著降低（P〈0．05），但治疗组下降程度更明显（P〈0．05）；两组患者HDL—C均升高（P〈0．05），但治疗组升高程度更明显（P〈0．05）；hs-CRP、TNF-α浓度均明显降低（P〈0．05），但治疗组降低程度更明显（P〈0．05）；两组颈动脉IMT均变薄（P〈0．05），但治疗组明显变薄（P〈0．05）。结论阿托伐他汀钙片联合通心络胶囊具有调脂及较强抗炎、抗动脉硬化作用，可逆转或延迟颈动脉粥样硬化的进程。

Effect of atorvastatin calcium tablets combined with tongxinluo capsule on intlma-media thickness of the com- mon carotid artery and the levels of plasm inflammation markers

Objective To investigate the effects of atorvastafin calcium tablets combined with tongxinluo capsule on intima-media thickness （IMT） of the common carotid artery and the levels of plasm inflammation markers in patients with hyperlipidemia and carotid artery atheroselerosis. Methods Seventy patients with hyperlipidemia and carotid artery atherosclerosis were randomly divided into the treatment group and control group. Both were given general treatment. The treatment group were given atorvastafin calcium tablets 20 mg, once a day, combined with tongxinluo capsule, 4 tablets, three times a day. Meanwhile, the control group were only given atorvastatin calcium tablets 20 mg, once a day. Both were treated for 12 weeks. The levels ofTC, TG, LDL-C, HDL-C, hs-CRP, TNF-α were determined and color doppler echo-cardiography was used to measure IMT of the common carotid artery before the entry into the trial and after 12 weeks of the trial, respectively. Results After 12 weeks, the concentration level of TC, TG, LDL-C, hs-CRP, TNF-α, IMT were all decreased significantly （ P 〈 0. 05 ）, meanwhile, HDL-C was increased significantly （P 〈 0.05） in both groups. But in treatment group, the concentration level of TC, TG, LDL-C, hs-CRP, TNF-ct, IMT were significantly lower and HDL-C was higher than those in control group （P 〈 0. 05 ）. Conclusion Atorvastatin calcium tablets combined with tongxinluo capsule can effecfly regulate blood fat, reduce inflammation, resist arteriosclerosis and reverse or delay the process of the carotid artery atherosclerosis.