2型糖尿病大血管病变与血清脂联素及C反应蛋白关系的研究

目的探讨2型糖尿病患者血清脂联素及C反应蛋白水平与大血管病变的关系。方法糖尿病患者63例，按颈动脉内膜中层厚度（CIMT）将其分为：CIMT≥1mm者为A组；CIMT〈1mm者为B组；健康体检者作为对照C组。分别检测身高、体重、血脂、血糖、空腹胰岛素、脂联素（APN）、C反应蛋白（CRP），计算体重指数及胰岛素抵抗指数（IRI），并进行统计学分析。结果A组及B组血清APN水平低于C组（P〈0．01），A组血清APN水平低于B组（P〈0．01）；A组及B组血清CRP水平高于C组（P〈0．01），A组血清CRP水平高于B组（P〈0．05）。CIMT与APN、HDL呈显著负相关，与HOMA-IR、CRP呈显著正相关。进入回归方程的因素为CRP、APN、FBG、HDL、HOMA—IR。结论血清APN水平降低、CRP水平升高是2型糖尿病患者颈动脉内膜增厚的主要危险因素，参与2型糖尿病大血管病变的发生和发展。

Relationship of macroangiopathy with serum adiponectin and C reactive protein in type 2 diabetes patients

Objective To study the relationship of the serum adiponeetin （APN） and C-reactive protein （CRP） with maemangiopathy in type 2 diabetic patients. Methods Sixty-three type 2 diabetes patients were divided into two groups depending on the carotid infima-media thickness （CIMT） value （CIMT≥ 1 mm as group A, CIMT 〈 1 mm as group B）. The normal controls was enrolled in this study as control group （ group C）. The height, weight, blood glucose,blood fat, fasting insulin, serum APN, CRP and CIMT in these patients were determined. The body mass index （BMI） and insulin resistance index（IRI） in these patients were calculated, then above indexes were analyzed statistiealy. Results The serum APN of group A and B were lower than that group C （P 〈0.01 ） and the serum APN of group A was lower than that of group B（P 〈0. 01 ）. The serum CRP of group A and B were higher than that of group C （P 〈 0. 01 ）, and the serum CRP of Group A were higher than that of group B （P 〈 0. 05 ）. CIMT was negatively correlated with APN and HDL,while positively correlated with HOMA-IR, CRP. FBG, HDL, CRP and APN were entered in the regression equation. Conclusion The reducing of the level of serum adiponectin, the elevating of CRP are major risk factors of carotid artery intimal thicken/rig in type 2 diabetes patients and involved in occurrence and development of macroangiopathy in type 2 diabetes patients.