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Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases
Authors:Ashton A. Connor  Robert E. Denroche  Gun Ho Jang  Mathieu Lemire  Amy Zhang  Michelle Chan-Seng-Yue  Gavin Wilson  Robert C. Grant  Daniele Merico  Ilinca Lungu  John M.S. Bartlett  Dianne Chadwick  Sheng-Ben Liang  Jenna Eagles  Faridah Mbabaali  Jessica K. Miller  Paul Krzyzanowski  Heather Armstrong  Steven Gallinger
Affiliation:1. PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada;2. Diagnostic Development, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada;3. Genomics, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada;4. Genome Sequence Informatics, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada;5. Department of Surgery, University of Toronto, Toronto, ON M5T 1P5, Canada;6. Deep Genomics, Inc., Toronto, ON M5G 1L7, Canada;7. The Centre for Applied Genomics (TCAG), The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada;8. UHN Biobank, University Health Network, Toronto, ON M5G 2M9, Canada;9. Department of Pathology, University Health Network, Toronto, ON M5G 2M9, Canada;10. Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network, Toronto, ON M5G 2M9, Canada;11. Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada;12. Division of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada;13. Division of Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada;14. Hepatobiliary/Pancreatic Surgical Oncology Program, University Health Network, Toronto, ON M5G 2M9, Canada;15. Department of Pathology, McGill University Health Centre, Montreal, QC H4A 3J1, Canada;16. Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada;17. Department of Pathology, Memorial Sloan Kettering Cancer Centre, New York, NY 10065, USA;18. Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA;19. Mayo Clinic College of Medicine, Rochester, MN 55905, USA;20. University of Nebraska Medical Centre, Omaha, NE 68198, USA;21. Massachusetts General Hospital, Boston, MA 02114, USA;22. Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada;23. Department of Surgery, Kingston General Hospital, Kingston, ON K7L 2V7, Canada;24. Pancreatic Cancer Translational Research Laboratory, Oncology Institute, Sheba Medical Center, Tel Hashomer, Israel;25. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;26. Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada;27. Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada;28. Goodman Cancer Research Centre, Montreal, QC H3A 1A3, Canada
Abstract:
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  • Keywords:pancreatic ductal adenocarcinoma  metastases  mutational signatures  driver genes  cell cycle progression  hypoxia  whole-genome sequencing  RNA sequencing
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