Topical application of povidone‐iodine before wound closure is associated with significant increase in serum iodine level

Aim: To determine serum iodine level before and after local application of povidone‐iodine before wound closure in cardiac surgery patients. Povidone‐iodine is a popular antiseptic solution that has been widely used in perioperative wound management of surgical patients. Despite its widespread usage, little is known concerning the absorption profile and potential systemic toxicity. Methods: We carried out a prospective study on the serum iodine level and corresponding renal function in consecutive patients operated on at our cardiac surgical unit. Results: There was a statistically significant increase in serum iodine level and patients with impaired renal function defined by creatinine level showed significantly higher postoperative iodine levels. Conclusion: Systemic iodine absorption is evidence that, even with single wound irrigation, repeated usage should be avoided in patients with renal impairment.