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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
Authors:Alessandro Carugo  Rosalba Minelli  Luigi Sapio  Melinda Soeung  Federica Carbone  Frederick S. Robinson  James Tepper  Ziheng Chen  Sara Lovisa  Maria Svelto  Samirkumar Amin  Sanjana Srinivasan  Edoardo Del Poggetto  Sara Loponte  Francesca Puca  Prasenjit Dey  Gabriel G. Malouf  Xiaoping Su  Giannicola Genovese
Affiliation:1. Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA;2. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA;3. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA;4. Telethon Institute of Genetics and Medicine, Via Campi Flegrei 34, Pozzuoli 80078, Italy;5. The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT 06032, USA;6. Centre Hospitalier Régional et Universitaire Strasbourg, Hôpital Civil, 1 Place de L’Hôpital, Strasbourg 67091, France;7. Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université de Strasbourg, Illkirch 67400, France;8. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA;9. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou 510060, China;10. Department of Pathology, Texas Children''s Hospital, 6621 Fannin Street, Houston, TX 77030, USA;11. Department of Pathology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA;12. Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA;13. Department of Pathology, Johns Hopkins University, 600 N. Wolfe Street/Carnegie 417, Baltimore, MD 21287, USA;14. Dipartimento di Patologia Generale, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Roma 00168, Italy;15. Sheikh Ahmed Bin Zayed Al Nahyan Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA;16. Center for Precision Environmental Health, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;17. Department of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA;18. Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA;19. Department of Oncology, St. Jude Children''s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38120, USA;20. Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA;21. David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Abstract:
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  • Keywords:rhabdoid tumors  renal medullary carcinoma  embryonic mosaic GEM models  SMARCB1  MYC  p53  BIRC5  ER stress  autophagy  proteasome inhibitors
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