Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT |
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| Authors: | Philipp M. Amann Dirk Schadendorf Robert W. Owen Bernhard Korn Stefan B. Eichmüller Alexandr V. Bazhin |
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| Affiliation: | 1. Skin Cancer Unit, German Cancer Research Center Heidelberg and Department of Dermatology, University of Heidelberg, University Hospital Mannheim, Mannheim, Germany;2. Department of Dermatology, University Hospital Essen, Essen, Germany;3. Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany;4. Genomics and Proteomics Core Facility, German Cancer Research Center, Heidelberg, Germany;5. Surgery Department, University Hospital Heidelberg, Heidelberg, Germany |
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| Abstract: | Please cite this paper as: Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT. Experimental Dermatology 2010. Abstract: Vitamin A is a pivotal regulator of differentiation and growth of developing and adult skin. Retinoic acid is the major physiologically active form of vitamin A regulating the expression of different genes through retinoic acid nuclear receptors. Here, we present evidence that other vitamin A derivates – retinol and retinal – are also capable of functioning as regulators of gene expression in the keratinocyte cell line HaCaT. We have shown that all‐trans retinol (ATRol) and all‐trans retinal (ATRal) are capable of modulating gene expression in keratinocytes, which is not because of vitamin A metabolism in the cells, and retinol and retinal modulate gene expression through nuclear receptors: retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Based on the data, we propose that ATRol and all‐trans retinal, in addition to all‐trans retinoic acid, can function as important regulators of gene expression manifesting their effect through the nuclear receptors RARs and RXRs. |
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| Keywords: | HaCaT keratinocytes regulation of gene expression retinoids |
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