Attenuation of ischemia reperfusion-induced lung edema by prostaglandin I2 analogue OP-2507 in the isolated perfused rat lung

Using the physiological salt solution (PSS)/Ficollperfused rat lung, we studied the effect of prostaglandin I₂ (PGI₂) analogue, OP-2507, on ischemia-reperfusion lung injury. Ischemia was induced by stopping perfusion and ventilation. Reperfusion after 90 min of normothermic ischemia increased mean pulmonary artery perfusion pressure (Ppa) and produced significant lung edema. Pretreatment with OP-2507 (200 ng·ml⁻¹ and 1000 ng·ml⁻¹) equally attenuated the increase in Ppa and lung edema after reperfusion. Lactate dehydrogenase release from the OP-2507-treated lungs of both doses were significantly lower than the untreated lungs. Thus, OP-2507 seems to be a useful agent for preventing ischemia-reperfusion lung injury.