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Defining antimicrobial resistance in cystic fibrosis
Authors:Timothy J. Kidd  Rafael Canton  Miquel Ekkelenkamp  Helle Krogh Johansen  Peter Gilligan  John J. LiPuma  Scott C. Bell  J. Stuart Elborn  Patrick A. Flume  Donald R. VanDevanter  Valerie J. Waters
Affiliation:1. School of Chemistry and Molecular Biosciences, The University of Queensland, Lung Bacteria Group, QIMR Berghofer Medical Research Institute, Brisbane, Australia;2. Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain;3. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands;4. Department of Clinical Microbiology, Rigshospitalet, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark;5. Clinical Microbiology-Immunology Laboratories, UNC HealthCare, Chapel Hill, NC, USA;6. Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA;7. Department of Thoracic Medicine, The Prince Charles Hospital and QIMR Berghofer Medical Researhc Institute, Brisbane, Australia;8. Imperial College and Royal Brompton Hospital, London, Queen''s University Belfast, United Kingdom;9. Departments of Medicine and Pediatrics, Medical University of South Carolina, Charleston, SC, USA;10. Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA;11. Division of Infectious Diseases, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, USA
Abstract:
Antimicrobial resistance (AMR) can present significant challenges in the treatment of cystic fibrosis (CF) lung infections. In CF and other chronic diseases, AMR has a different profile and clinical consequences compared to acute infections and this requires different diagnostic and treatment approaches. This review defines AMR, explains how it occurs, describes the methods used to measure AMR as well as their limitations, and concludes with future directions for research and development in the area of AMR in CF.
Keywords:on behalf of the
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