Claudin-1、Id-1、Id-3蛋白在胃癌中的表达及临床意义

目的研究胃癌组织Claudin-1、Id-1、Id-3表达与胃癌细胞分化、增殖、侵袭转移和预后的关系。方法应用免疫组织化学检测Claudin-1、Id-1、Id3-蛋白在胃癌组织中的表达。结果Claudin-1表达水平与胃癌组织学类型、肿瘤侵袭程度及淋巴结转移相关（P〈0．05），Id-1蛋白表达与胃癌淋巴结转移呈负相关（P〈0．05）；Id-3蛋白表达在不同组织起源的胃癌之间差异有统计学意义（P〈0．05）；Claudin-1作为细胞间紧密连接的构成成份在胃癌组织中的表达作用与Id蛋白表达正相关。结论Claudin-1表达上调以及在胃癌侵袭过程中表达转化提示参与肿瘤的生物学行为的转化；Id-1在胃癌淋巴结转移的预测中有一定的应用价值；不同组织起源的胃癌Id-3呈差异性表达；Claudin及Id蛋白在胃癌的侵袭转移及临床治疗及预后判断有一定的应用价值。

Study on the expression of Claudin-1, Id-1, ld.3 and their clinical signiflicance in gastric carcinoma

Objective To investigate the relationship of the expression of Ciaudin-1, Id-1, Id-3 and gastric carcinoma cell differentiation, proliferation, invasion and metastasis and prognosis. Methods By using Envision immunohistochemistry detected the expression of Claudin-1, IdA, Id3-protein in gastric carcinoma. Re-sults Claudin-1 expression was correlated with the histological type of gastric carcinoma, the extent of tumor in-vasion and lymph node metastasis (P < 0.05), Id-1 protein expression in gastric carcinoma with lymph node neg-ative correlation(P <0. 05); the difference of Id-3 protein expression in different organization original gastric carcinoma was statistically significant (P < 0. 05) ; the expressed effect of Claudin-1 cells as close connection composition in gastric carcinoma tissue was direct correlated to the Id protein expression. Conclusion The up-regulation of Claudin-1 expression and their expression transformation in the process of gastric carcinoma inva-sion prompted they participated in the transformation of tumor biological behaviour; Id-1 in the forecast of lymph node metastasis in gastric carcinoma had utilized utilized value, Id-3 in different organization original gastric car-cinoma expressed difference, Clandin and Id protein in gastric carcinoma invasion metastasis and clinical treat-ment and prognosis criterion had certain utilized value.