Sexual dimorphism of stress-induced changes in renal peripheral benzodiazepine receptors in rat. |
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| Authors: | R C Drugan P V Holmes A P Stringer |
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| Affiliation: | Schrier Research Laboratory, Department of Psychology, Brown University, Providence, RI 02912. |
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| Abstract: | Adult male and female rats were exposed to either inescapable shock or no treatment. In vitro [3H]Ro 5-4864 (4'-chlorodiazepam) binding (1 nM) to peripheral benzodiazepine receptors (PRB) in both CNS and peripheral tissues indicated no gender differences in olfactory bulb, heart, lung or adrenal gland but a significant effect was observed in renal tissue. Female rats showed an attenuated stress-induced reduction (23%) in PBR in comparison to males (55%). This difference was shown to be an alteration of Bmax and not kD by Scatchard analysis. These data are the first demonstration of a sexual dimorphism in environmentally-induced alterations in PBR. |
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