VX2荷瘤兔肝脏肿瘤氩氦刀治疗后的近期超声造影

目的  了解超声造影对氩氦刀治疗VX2兔肝脏肿瘤近期疗效的应用价值。方法  两组实验兔行氩氦刀冷冻治疗,其中荷瘤兔冷冻治疗组（A组）30只,正常肝冷冻对照组（B组）10只,分别于术前、术后1d、1周、2周采用新型超声造影剂六氟化硫以及造影软件造影多普勒序列（contrast pulse sequencing,CPS）进行实验,观察疗效。结果     ①A组76.7%（23/30）和B组100%（10/10）的消融区,超声造影显示各期均无异常增强,判断肿瘤完全灭活;②A组23.3%（7/30）的消融区,超声造影显示局部有早期增强,提示肿瘤残存;③消融区边缘充血水肿带造影表现为动脉期环状高增强,门脉期及延迟期增强信号与肝实质相似;消融区边缘残留灶的造影与肿瘤病灶治疗前的造影表现一致。结论  超声造影是肝脏肿瘤氩氦刀治疗后近期疗效评价的重要手段。

Recent ultrasound contrast of the VX2 liver tumor in a rabbit model after cryosurgical treatment

Objective  To evaluate the role of enhanced ultrasonography in assessing the short term therapeutic response to Ar-He cryoablation for VX2 liver tumor. Methods  30 rabbits with VX2 tumor (group A) and 10 healthy rabbits (group B) underwent Ar-He cryoablation for the tumor and liver respectively. The contrast agent SonoVue and contrast pluse sequencing（CPS）software technology were used to evaluate the role of Ar-He before cryoablation and 1day, 1week and 2 weeks after cryoablation. Results   ①76.7 percent (23/30) of lesions in group A and 100.0 percent(10/10) of lesions in group B showed no enhancement within entire procedural periods, which indicated complete necrosis. ②23.3 percent (7/30) of lesions in group A showed local enhancement in the arterial phase, and new lesions found in the liver suggested tumor residue. ③The ring of inflammatory hyperemia enhanced in the arterial phase, and the enhancement signal in the portal phase and delayed phase was the same as the liver parenchyma. The imaging findings of the tumor residue were the same as non-cryoablation. Conclusion   Imaging characteristics of contrast enhanced ultrasound(CEUS) after treatment are helpful to evaluate the effect of the cryoablation for liver cancer.