深海鱼油对血脂异常人群的血脂和血糖影响

目的探究深海鱼油对血脂异常人群的血脂和血糖影响。方法采用随机、2×2交叉实验设计的方法,对60名血脂异常患者分别进行3月的深海鱼油干预和3月的空白对照,深海鱼油干预剂量为1.8 g/d。采用全自动生化仪,对患者的血脂和血糖指标进行检测。运用交叉设计资料的方差分析方法探讨鱼油对血脂和血糖水平的影响。结果与空白对照组相比,深海鱼油干预可降低血清总胆固醇(鱼油干预组vs空白对照组,(5.09±0.79)mmol/L vs(5.60±0.89)mmol/L,P=0.003]、甘油三酯(鱼油干预组vs空白对照组,(1.67±0.09)mmol/L vs(2.10±0.09)mmol/L,P=0.003]和低密度脂蛋白(鱼油干预组vs空白对照组,(3.51±0.92)mmol/L vs(3.88±0.95)mmol/L,P=0.020]水平,而两组人群的高密度脂蛋白、空腹血糖和餐后血糖水平无统计学差异。结论鱼油干预可以明显改善血脂异常人群血脂水平,对血糖水平并未产生影响。

EFFECTS OF MARINE FISH OIL ON LIPID PROFILE AND BLOOD GLUCOSE IN ADULTS WITH DYSLIPIDEMIA

Objective To investigate the effects of marine fish oil supplementation on lipid profile and blood glucose in adults with dyslipidemia.Methods In a randomized,2×2 cross-over design,60 subjects were divided into either 3-mo supplementation with marine fish oil group or control group.The participants of marine fish oil group were required to take 1.8g marine fish oil per day.The effect of marine fish oil group supplementation on lipid profile and blood glucose were analyzed with cross-over ANOVA.Results Compared with control group,subjects in fish oil supplementation group had significantly lower levels of serum total cholesterol((5.09±0.79)mmol/L vs(5.60±0.89)mmol/L,P=0.003),triglyceride((1.67±0.09)mmol/L vs(2.10±0.09)mmol/L,P=0.003)and low density lipoprotein((3.51±0.92)mmol/L vs(3.88±0.95)mmol/L,P=0.020).There were no significant differences between the two groups in high density lipoprotein,fasting blood glucose and postprandial blood glucose.Conclusion The fish oil supplementation can significantly improve blood lipid profile in adults with dyslipidemia,but without significant effect on blood glucose.