3-芳基/芳氧甲基-6-芳基-1,2,4-三唑并［3,4-b］-1,3,4-噻二唑衍生物的合成及生物活性

噻二唑类杂环化合物有广泛的生物活性，如消炎、驱虫、除草、调节植物生长、防止水稻白叶枯病、柑桔溃疡病、蕃茄青枯病等［１～３］。而１，２，４三唑类杂环化合物也有相当广泛的生物活性，如抗菌、抗痉挛、消炎、抗血小板凝聚及调节植物生长等［４～６］。如果合成既...

SYNTHESIS AND BIOLOGICALACTIVITIES OF DERIVATIVES OF3-ARYL/ARYLOXYMETHYL-6-ARYL-1,2,4-TRIAZOLO

AIM: To synthesize a number of novel heterocyclic compounds and screen for their biological activities. Sixteen title compounds were prepared. METHODS: These novel compounds were prepared by the reaction of 3 aryl/aryloxymethyl 4 amino 5 mercapto 1,2,4 triazoles with aryl carboxylic acids in the presence of phosphorus oxychloride. The structures of these compounds were confirmed by elemental analysis, IR, 1HNMR and MS. The reaction conditions for the synthesis had been investigated. All the compounds were screened for antimicrobial activity against bacteria S.aureus, E.coli and B.subilis . The concentration of the test compounds was 0 002%. The antibacterial activities of the test compounds were compared with those of penicillin and gentamicin. RESULTS: The results display that some of them possess strong biological activities.CONCLUSION: Syntheses of these novel heterocyclic compounds and study on their biological activities are very important and valuable in medicine.