Experimental evidence for the probable involvement of calcium ion transport in 67Ga uptake by tumour cells

The study of ⁶⁷Ga-citrate uptake and calcium transport in Ehrlich ascites tumour cells seems to indicate that their peculiar characteristic of increased permeability to extracellular calcium ion might be responsible for their ⁶⁷Ga accumulation. Experiments performed under different conditions of extracellular calcium, temperature, and presence of ionophore and other plasma membrane modifying agents such as lanthanum appear to corroborate this hypothesis.