PCOS患者血浆leptin和血清T、E2、FSH、LH、PRL检测的临床意义

目的：探讨多囊卵巢综合征（PCOS）患者血浆leptin和血清T、E2、FSH、LH、PRL水平的变化及临床意义。方法：应用放射免疫分析和发光法对31例PCOS患者进行了血浆leptin和血清T、E2、FSH、LH、PRL测定,并以正常妇女作对照。结果：PCOS患者血浆leptin和血清T、LH、PRL水平非常显著地高于正常妇女组（P〈0.01）,FSH、E2水平与正常妇女组比较无显著性差异（P〉0.05）,且血浆leptin水平与血清T、LH、PRL水平呈正相关（r=0.5784、0.5411、0.6082,P〈0.01）。结论：检测PCOS患者血浆leptin和血清T、E2、FSH、LH、PRL水平的变化与疾病的发生和发展密切相关。

Clinical Significance of Changes of Plasma Leptin and Serum T, E2, FSH, LH,PRL Levels in Patients with Polycystic Ovary Syndrome (PCOS)

Objective To explore the clinical significance of changes of plasma leptin and serum T,E2,FSH,LH,PRL levels in patients with polycystic ovary syndrome（PCOS）.Methods Plasma leptin（with RIA）,serum T,E2,FSH,LH,PRL（with ECLIA）levels were detected in 31 patients with polycystic ovary syndrome（PCOS）as well as in 35 controls.Results The plasma leptin and serum T,LH,PRL levels in the patients with PCOS were significantly higher than those in controls（P〈0.01）,while the serum E2,FSH levels were not significantly different from those in controls（P〉0.05）.Plasma leptin levels were positively correlated with those of serum T,LH,PRL（r=0.5784,0.5411,0.6082,P〈0.01）.Conclusion Development of PCOS was closely related to the plasma leptin and serum T,LH,PRL levels.