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Elevated plasma homovanillic acid in depressed females with melancholia and psychosis |
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| Authors: | D P Devanand M B Bowers F J Hoffman J C Nelson |
| Affiliation: | 1. Davangere P. Devanand, M.D., is Postdoctoral Fellow in Psychiatry, Yale University School of Medicine, New Haven, CT, USA;2. Malcolm B. Bowers, Jr., M.D., is Professor of Psychiatry, Yale University School of Medicine, New Haven, CT, USA;3. Frederick J. Hoffman, Jr., is Assistant in Research, Yale University School of Medicine, New Haven, CT, USA;4. J. Craig Nelson, M.D., is Associate Professor of Psychiatry, Yale University School of Medicine, New Haven, CT, USA |
| Abstract: | Plasma free homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) were measured before drug treatment in 29 patients diagnosed as having major depression with melancholia and in 18 control subjects. Plasma HVA was significantly elevated in the total group of female melancholic patients when compared with female controls or male melancholics. Most female patients with psychotic melancholia had elevated HVA levels. These differences were not found in male patients. No significant differences were found for plasma MHPG. |
| Keywords: | Melancholia psychosis homovanillic acid 3-methoxy-4-hydroxy-phenylglycol |
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