Efficacy of Trivalent Seasonal Influenza Vaccination in Reducing Mortality and Hospitalization in Chinese Nursing Home Older Adults |
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Authors: | Tuen-Ching Chan Ivan Fan-Ngai Hung James Ka-Hay Luk Patrick Chiu-Yat Woo Leung-Wing Chu Felix Hon-Wai Chan |
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Affiliation: | 1. Department of Medicine and Geriatrics, The University of Hong Kong, Fung Yiu King Hospital, Hong Kong SAR, China;2. Division of Geriatrics, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China;3. Division of Infectious Disease, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China;4. Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China |
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Abstract: | ObjectiveTo examine the clinical efficacy of the trivalent seasonal influenza vaccination among Chinese older adults residing in a nursing home.DesignA 12-month prospective cohort study. Participants were divided into 2 groups based on their own choice on vaccination of trivalent seasonal influenza vaccine: vaccinated group and unvaccinated group.SettingFifty-eight nursing homes in Hong Kong.ParticipantsA total of 1859 older adults residing in a nursing home.MeasurementsAll-cause mortality, pneumonia-related mortality, all-cause hospitalization, and pneumonia-related hospitalization.ResultsA total of 1859 older adults residing in a nursing home were included: 1214 (65.3%) in the vaccinated group and 645 (34.7%) in the unvaccinated group. At 12 months of study, for all-cause mortality, 14.6% (177 of 1214) of the vaccinated group and 20.2% (130 of 645) of the unvaccinated group had died (P < .001). Multivariate analysis showed the hazard ratio for the vaccinated group was 0.72 (95% confidence interval [CI]: 0.54–0.95; P < .01). For pneumonia-related mortality, 9.4% (114 of 1214) of the vaccinated group and 12.7% (82 of 645) of the unvaccinated group died (P = .033). Multivariate analysis showed the hazard ratio for the vaccinated group was 0.80 (CI: 0.62–0.98; P < .05). The median number of all-cause hospitalizations per 1000 person-months was 55 (0–111) for the vaccinated group and 55 (0–167) for the unvaccinated group (P < .01). The median number of pneumonia-related hospitalizations per 1000 person-months was 0 (0–55) for the vaccinated group and 0 (0–111) for the unvaccinated group (P < .01).ConclusionsVaccination of trivalent seasonal influenza vaccine in Chinese nursing home older adults significantly reduced all-cause and pneumonia-related mortality and hospitalization. |
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Keywords: | Efficacy influenza vaccination nursing home mortality hospitalization Chinese |
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