| 泛素连接酶Pirh2在肿瘤中的研究进展 |
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| 引用本文： | 吴小荣,刘东明.泛素连接酶Pirh2在肿瘤中的研究进展[J].国外医学(肿瘤学分册),2012(11):824-826,880. |
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| 作者姓名： | 吴小荣 刘东明 |
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| 作者单位： | 上海交通大学医学院附属仁济医院泌尿外科,200001 |
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| 摘 要： | 泛素连接酶Pirh2是体内E3泛素连接酶的一种，可通过泛素一蛋白酶体途径介导p53降解，抑制p53的生物学功能。近来研究表明Pirh2在人体多种肿瘤细胞中呈过度表达，提示其可能参与肿瘤发生和发展过程，将来可能作为肿瘤基因治疗的一个潜在靶点。
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| 关 键 词： | 肿瘤 泛素蛋白连接酶类 Pirh2 |
Pirh2 and tumor |
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| WU Xiao-rong,LIU Dong-ming.Pirh2 and tumor[J].Foreign Medical Sciences (Cancer Section),2012(11):824-826,880. |
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| Authors: | WU Xiao-rong LIU Dong-ming |
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| Institution: | . Department of Urology Surgery, Renji Hospital, Shanghai Jiaotong University Medical School, Shanghai 200001, China |
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| Abstract: | Pirh2 （ p53-induced protein with a Ring-H2 domain） , one of the ubiquitin-protein E3 ligases, can promote p53 degradation via ubiquitin-proteasome pathway, and repress the biological functions of p53. Researchers have found that the Pirh2 is overexpressed in many cancers, which suggests Pirh2 is probably correlated with tumorigenesis and cancer development, and it may become a promising cancer therapeutic target. |
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| Keywords: | Neoplasms Ubiquitin-protein ligases Pirh2 |
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