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| 抗衰老中药筛选：进展与挑战 | |
| 引用本文： | 李春生,邓洪斌,李电东,LI Zhao-he. 抗衰老中药筛选：进展与挑战[J]. 中国结合医学杂志, 2013, 19(4): 243-252. DOI: 10.1007/s11655-013-1432-8 |
| 作者姓名： | 李春生 邓洪斌 李电东 LI Zhao-he |
| 作者单位： | Xiyuan Hospital,China Academy of Chinese Medical Sciences;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College;Fengsheng Orthopedics Specialist Hospital |
| 摘 要： | To provide a better service for senior health care,we summarized screening studies of traditional Chinese anti-aging materia medica(TCAM).We collected and analyzed literature of TCAM screening studies using the lifespan test and animal models of aging from 1984 to 2012.We found 26 screening methods for TCAM,and 153 single herbs or active ingredients of TCAM that have been screened out during the past 28 years.The cell lifespan test,the fruit fly lifespan test, and D-galactose aging model were the most widely used and intensively studied screening methods.However,the method for establishing the D-galactose aging model needs to be standardized,and the D-galactose aging model cannot completely be a substitute for the normal aging mouse model.Great success has been achieved in screening studies in TCAM.To further improve screening studies in TCAM,we suggest that the D-galactose aging model be incorporated into the lifespan test in the New Drugs of Traditional Chinese Medicine Research Guide. |
| 关 键 词： | Chinese anti-aging materia medica lifespan test animal model of aging screening research |
Advances and Challenges in Screening Traditional Chinese Anti-Aging Materia Medica |
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| LI Chun-sheng and DENG Hong-bin,LI Dian-dong,LI Zhao-he. Advances and Challenges in Screening Traditional Chinese Anti-Aging Materia Medica[J]. Chinese journal of integrative medicine, 2013, 19(4): 243-252. DOI: 10.1007/s11655-013-1432-8 | |
| Authors: | LI Chun-sheng DENG Hong-bin LI Dian-dong LI Zhao-he |
| Affiliation: | 11432. Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China 21432. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China 31432. Fengsheng Orthopedics Specialist Hospital, Beijing, 100034, China |
| Abstract: | To provide a better service for senior health care, we summarized screening studies of traditional Chinese anti-aging materia medica (TCAM). We collected and analyzed literature of TCAM screening studies using the lifespan test and animal models of aging from 1984 to 2012. We found 26 screening methods for TCAM, and 153 single herbs or active ingredients of TCAM that have been screened out during the past 28 years. The cell lifespan test, the fruit fly lifespan test, and D-galactose aging model were the most widely used and intensively studied screening methods. However, the method for establishing the D-galactose aging model needs to be standardized, and the D-galactose aging model cannot completely be a substitute for the normal aging mouse model. Great success has been achieved in screening studies in TCAM. To further improve screening studies in TCAM, we suggest that the D-galactose aging model be incorporated into the lifespan test in the New Drugs of Traditional Chinese Medicine Research Guide. |
| Keywords: | Chinese anti-aging materia medica lifespan test animal model of aging screening research |
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