Biochemical and immunohistochemical studies on carcinoembryonic antigen of ovarian mucinous and serous tumors |
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| Authors: | Toshimitsu Tohya M.D. Teruo Iwamasa M.D. Masao Maeyama M.D. |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, Kumamoto University Medical School, Kumamoto 860, Japan;1. Department of Pathology, Ryukyu University Medical School, Okinawa 903-01, Japan;1. Mater Health Services, Raymond Terrace, Brisbane, QLD 4101, Australia;2. School of Medicine, University of Queensland, St Lucia, QLD 4072, Australia;3. UQ/Mater McAuley Library, The University of Queensland Library, Brisbane 4101, Australia;4. Princess Alexandra Hospital, Ipswich Road, Woolloongabba, QLD 4102, Australia;1. Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, 80 Daehakro, Buk-gu, Daegu-city 41566, Republic of Korea;2. School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, PR China;1. Guangxi Key Laboratory of Information Materials, Guilin University of Electronic Technology, Guilin 541004, PR China;2. Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, Canada M1C 1A4;3. Department of Sanitary Chemistry, Public Health School, West China Medical Center, Sichuan University, Chengdu 610044, PR China;4. Department of Chemistry, University of Toronto, Toronto, Canada M5S 3H6;1. Department of Chemistry, Alfaisal University, Al Zahrawi Street, Al Maather, Al Takhassusi Road, Riyadh 11533, Saudi Arabia;2. King Faisal Specialist Hospital and Research Center, Zahrawi Street, Al Maather, Riyadh 11211, Saudi Arabia;3. Section of Pediatric Allergy and Immunology, Department of Pediatrics, King Faisal Specialist Hospital & Research Centre (KFSH-RC), Riyadh, Saudi Arabia;1. Department of Medical Biochemistry &Molecular biology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia Postal Code: 32511, Egypt;2. Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Menoufia University, Egypt;3. Department of Cardiothoracic Surgery, Faculty of Medicine, Menoufia University, Egypt;4. Department of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Egypt |
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| Abstract: | ![]()
The carcinoembryonic antigen (CEA) in the cyst fluid of ovarian mucinous and serous tumors was investigated. The molecular weight and antigenicity of the CEA from both ovarian tumors were very similar to those of colon cancer CEA as determined by SDS electrophoresis and double immunodiffusion on agar plates. In the cyst fluid of ovarian mucinous tumors, the amount of CEA was generally high and CEA of molecular weight (MW) 200,000 was increased. In contrast, in the cyst fluid of ovarian serous tumors, the CEA amount was low and CEA variants of MW 370,000 and 180,000 were present in addition to the main CEA of MW 200,000. Immunohistochemically, CEA was stained mainly in the intestinal type epithelium of ovarian mucinous tumors, and the CEA revealed a tendency to be stained more frequently and strongly with increasing degree of tumor malignancy. Thus, ovarian mucinous tumors (especially the intestinal type epithelium) produced large amounts of CEA which closely resembled colon cancer CEA, whereas ovarian serous tumors produced small amounts of CEA, including some CEA variants. In the study of ovarian epithelial tumors, CEA may be useful as a marker for the malignant transformation of ovarian mucinous tumors. |
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