CXCR7与VEGF在结直肠癌组织中的表达及意义

目的 探讨趋化因子受体7（chemokine receptor 7,CXCR7）和血管内皮生长因子（vascular endothelial growth factor,VEGF）在结直肠癌组织中的表达及其与临床病理特征的关系.方法 采用免疫组织化学方法检测73例结直肠癌组织及20例癌旁正常组织CXCR7与VEGF的表达.结果 （1）CXCR7在癌旁正常组织中的阳性表达率为20.00％,癌组织中的阳性表达率为71.23％,其表达与浸润深度、淋巴结转移、TNM分期显著相关（P＜0.05）.（2）VEGF在癌旁正常组织中的阳性表达率为10.00％,癌组织中的阳性表达率为67.12％,其表达与浸润深度、淋巴结转移、TNM分期有显著相关性（P＜0.05）.（3）Spearman等级相关分析显示两者在结直肠癌组织中的表达呈正相关（rs=0.629,P＜0.05）.结论 CXCR7与VEGF在结直肠癌发展、侵袭和转移过程中起重要作用,并可能参与肿瘤血管形成为肿瘤进展提供物质基础.

Expression and significance of CXCR7 and VEGF in colorectal cancer tissues

Objective To investigate the relationship between the expressions of chemokine receptor 7 （CXCR7） and Vascular endothelial growth factor （VEGF） in colorectal cancer tissues and their clinic opathological features. Methods Immunohistochemistry was used to detect the expression of CXCR7 and VEGF in 73 cases of colorectal cancer tissues and 20 cases of normal tissues near the cancer. Results （1）CXCR7 expression in normal tissue was 20.00 %, the positive expression in cancer tissues was 71.23% , and its expression in colorectal cancer tissues were correlated closely with the extent of tumor invasive, TNM stages and lymph node metastasis （P 〈0.05 ）. （2）VEGF expression in normal tissue was 10.00 %, the positive expression in cancer tissues was 67.12% , and its expression in colorectal ＇cancer tissues were correlated closely with the extent of tumor invasive, TNM stages and lymph node metastasis （P〈0.05）. （3）Spearman rank correlation analysis showed that both the expression in colorectal cancer showed a positive correlation （rs = 0.629, P 〈0.05）. Conclusion CXCR7 and VEGF play an important role in the development, invasion and metastasis of colorectal cancer, and may be involved in tumor angiogenesis providing the material basis of tumor progression.