阿司匹林联合低分子肝素治疗血栓前状态致早期复发性流产的效果评价

目的探讨阿司匹林联合低分子肝素治疗血栓前状态致早期复发性流产的临床效果。方法选取2012年3月-2014年3月在我院就诊的160例复发性流产患者，随机分为治疗组和对照组，每组80例。另选80例正常生育期妇女用于LAR的测定。治疗组患者采用小剂量阿司匹林联合低分子肝素进行治疗，对照组患者采用低分子肝素进行治疗。对患者治疗前后凝血酶时间（TT）、D-二聚体（D—Dimer）和狼疮样抗凝物质（LA）等指标进行检测，对比分析两组患者的妊娠结局。结果治疗组治疗后TT、D—Dimer和IAR与对照组比较，差异具有统计学意义（P〈0．05）；治疗组活产率为83．75％明显高于对照组的57．50％（P〈0.05）。结论小剂量阿司匹林联合低分子肝素治疗血栓前状态早期复发性流产疗效显著，能缓解孕妇的血栓前状态，提高活产率，不良反应少，值得推广应用。

Evaluation the effect of aspirin combined with low molecular heparin in the treatment of prethrombotic state induced early recurrent spontaneous abortion

Objective To investigate the clinical effect of aspirin and low molecular heparin in the treatment of prethrombotic state induced early recurrent spontaneous abortion. Methods A total of 160 cases of patients with recurrent spontaneous abortion who were doctored in our hospital from March 2012 to March 2014, and it was randomly divided into treatment group and control group, each group of 80 cases. Another 80 cases of normal women of reproductive age for the detection of LAR. The treatment group was treated with small dose of aspirin and low molecular weight heparin, the control group was treated with low molecular weight heparin. Before and after treatment in patients with thrombin time （rIT）, two Ddimer （D-Dimer）, and lupus anticoagulant （LA） were tested and compared the pregnancy outcome of two groups of patients. Results The treatment group after treatment TT, D-Dimer and LAR compared with the control group, the difference was statistically significant （P〈0.05）; The live birth rate of treatment group was 83.75%, significantly higher than the control group （57.50%）（P〈0.05）. Conclusion Small dose of aspirin and low molecular weight heparin in the treatment of prethrombotic state early recurrent miscarriage is curative effect, it can alleviate the prethrombotic state of pregnant women, improve live birth rate, less adverse reactions, it is worthy of popularization and application.