髓系/前体NK细胞急性白血病及髓系/NK细胞急性白血病的回顾和进展

随着流式细胞术的普及，白血病的分类变得更为详细。髓系／前体NK细胞急性白血病及髓系／NK细胞急性白血病是目前认为的两种罕见白血病，在形态学上与常见白血病难以区分，表达髓系与淋系的双重抗原，预后较差，其独特的免疫表型是确诊的唯一依据。CD7分子与CD56分子在两种疾病的分类及临床表现中的作用引人关注。另一方面，随着基础研究的进展，NK细胞的分化途径也得到了进一步的认识。本文将就两种疾病的生物学起源、临床表现及诊断和治疗、CD56分子及CD7分子在两种疾病进程中所起的作用进行综述。

Myeloid/Natural Killer Cell Precursor and Myeloid/Natural Killer Cell Acute Leukemia Review

With the popularity of flow cytometry, the classification of leukemia become more detailed. Myeloid/ natural killer cell precursor acute leukemia and myeloid/natural killer cell acute leukemias are generally recognized as two kinds of rare leukemias and have poor prognosis. The cells expressed both myeloid and lymphatic antigens in these two leukemia and can not be diagnosed by morphology. The only basis to make a definite diagnosis is their unique Immunophenotyping. The role of CD7 and CD56 in these two leukemia are compelling, in the other hand, as the progress of cell differentiation research, there are many new awareness of NK cell differentiation. In this article, the biological origin, clinical manifestation, diagnosis, treatment and the role of CD7 and CD56 in these two leukemia are briefly summarized.